Southwest Cardiothoracic Anaesthesia

Article of the Month:

August 2026

JAMA article detailing how pre-operative and then on to post-operative administration of Dapaglifozin 10mg (4x doses in total) in patients undergoing cardiac surgery showed a reduction in post-operative AKI (28% vs 52% in the placebo group). AKI was defined as Creatinine > 1.5x of baseline, increase in Creatinine of > 26.5umol/l or oliguria of <0.5ml/kg/h for >6-12h post-operatively. There was no difference in post-operative AF or resternotomy rates.

SGLT2 Inhibitors for Prevention of AKI

This randomized clinical trial evaluates whether initiating dapagliflozin, compared with placebo, 1 day prior to elective cardiac surgery reduces the incidence of acute kidney injury at 7 days after surgery in adult patients.